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德意 科学家发现【虾青素】能有效地消除【紫外线UVA】对皮肤细胞的伤害

发布日期:2016-04-19

德意 科学家发现【虾青素】能有效地消除【紫外线UVA】对皮肤细胞的伤害

--湖北雅仕达生物技术有限公司 研发部 李昌军 译

     众所周知,虾青素是β-胡萝卜素的衍生物,因此有人产生虾青素和β-胡萝卜素功能等同的错误观念。不久前意大利和德国科学家合作,比较了虾青素、β-胡萝卜素、角黄素(另一种类胡萝卜素)预防紫外线UVA损伤皮肤细胞的功能。研究人员用适量的UVA照射人真皮纤维原细胞,结果显示,虾青素比β-胡萝卜素更能有效地消除UVA给真皮细胞带来的伤害。具体表现为虾青素能有效地阻止UVA处理后细胞活性氧的产生,保持细胞膜的完整,保护抗氧化酶CAT和SOD酶活性不受影响及抑制细胞程序性死亡;而β-胡萝卜素仅能部分保护抗氧化酶CAT和SOD酶活性;角黄素在本研究中基本没有表现生物学功能。除此之外,虾青素还具备其它优势:虾青素更容易被真皮纤维细胞吸收;在UVA的照射下稳定性更强;真皮纤维原细胞在相对高浓度的β-胡萝卜素(远低于实验中虾青素浓度)中,  UVA照射后细胞更容易死亡(细胞凋亡)。此研究报告名为《Astaxanthin, canthaxanthin and b-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes》,发表在《Experimental Dermatology》上。

【UVA】简介:

UVA波段,波长320~400nm,又称为长波黑斑效应紫外线 。它有很强的穿透力,可以穿透大部分透明的玻璃以及塑料。日光中含有的长波紫外线 有超过98%能穿透臭氧层和云层到达地球表面,UVA可以直达 肌肤的真皮层,破坏弹性纤维和胶原蛋白纤维(导致皱纹产生),同时将我们的皮肤晒黑。300-420nm波长的UVA紫外线可透过完全截止可见光的特殊着色玻璃灯管,仅辐射出以365nm为中心的近紫外光,可用于矿石鉴定、舞台装饰、验钞等场所。

英文文摘:

      Astaxanthin, canthaxanthin and b-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes     

      Emanuela Camera1,2, Arianna Mastrofrancesco1, Claudia Fabbri1, Felicitas Daubrawa2, Mauro Picardo1,Helmut Sies2 and Wilhelm Stahl2
      1Laboratorio di Fisiopatologia Cutanea, Istituto Dermatologico San Gallicano (IRCCS), Rome, Italy;
       2Institut fu¨r Biochemie und Molekularbiologie I, Heinrich Heine Universita¨t, Du¨sseldorf, Germany
      Correspondence: Emanuela Camera, Laboratorio di Fisiopatologia Cutanea, Istituto Dermatologico San Gallicano (IRCCS), Via Elio Chianesi 53,I-00128, Rome, Italy, Tel.: +39 (0)6   5266 6241, Fax: +39 (0)6 5266 6247, e-mail:
camera@ifo.it

Abstract: Carotenoids are used for systemic photoprotection in humans. Regarding mechanisms underlying photoprotective effects of carotenoids, here we compared the modulation of UVA-related injury by carotenoids. Human dermal fibroblasts (HDF) were exposed to moderate doses of UVA, which stimulated apoptosis,increased levels of reactive oxygen species and thiobarbituric acid reactive substances, decreased antioxidant enzymes activities,promoted membrane perturbation, and induced the expression of heme oxygenase-1 (HO-1). The carotenoids astaxanthin (AX),canthaxanthin (CX) and b-carotene (bC) were delivered to HDF 24 h before exposure to UVA. Astaxanthin exhibited a pronounced photoprotective effect and counteracted all of the above-mentioned UVA-induced alterations to a significant extent.b-Carotene only partially prevented the UVA-induced decline of catalase and superoxide dismutase activities, but it increased membrane damage and stimulated HO-1 expression. Moreover,bC dose-dependently induced caspase-3 activity following UVA exposure. In contrast, CX had no effect on oxidative damage,except for HO-1 expression, which was augmented. Uptake of AX by fibroblasts was higher than that of the other two carotenoids.The photostability of the three compounds in fibroblasts was AX > CX >> bC. The data indicate that the oxo-carotenoid AX has a superior preventive effect towards photo-oxidative changes in cell culture.

Key words: antioxidant enzymes – apoptosis – carotenes – skin photodamage – xanthophylls

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