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日本临床研究:虾青素能显著改善高氧化应激状态下人体的多项生理指标

发布日期:2016-04-19

湖北雅仕达生物生物技术有限公司 李昌军 编译

日本同志社大学抗衰老医学研究中心和富士化工合作的一项研究表明,天然虾青素可提高机体抗氧化能力、降低血压,减少下肢血管阻力,改善高氧化应激下妇女的身体症状。对一般人而言,氧化应激是一个陌生领域,它指的是体内高活性分子如活性氧自由基和活性氮自由基产生过多,超出机体清除氧化物的能力,即氧化系统和抗氧化系统失衡,进而导致组织损伤的过程。现代科学发现氧化应激除了与衰老相关外,它还是许多人类疾病背后真正的始作俑者,如糖尿病、心血管疾病等。

在本研究中,科学家首先用自由基检查分析系统对35名绝经后的健康女志愿者进行筛选,得到20名符合实验条件的高氧化应激妇女,其被要求每天服用12毫克天然虾青素。研究人员通过抗衰老共同生活质量问卷,体部测量,血液/尿液检查,氧化应力测试和血管功能检查等研究发现,服用天然虾青素对人体没有任何不良影响;从第4周开始,心脏收缩压和舒张压显著下降(即降压效果),眼疲劳、肩膀酸疼、白发、便秘、手脚冰凉及难以入睡的状况也得到显著的改善;在第8周时,体内的抗氧化指标(抗氧化能力的检测指标)明显升高,踝肱压力指数(评价下肢动脉狭窄指数)显著升高,也就是说下肢血流阻力减小,此结果与天然虾青素能改善血液的流动性,促进肩部、视网膜血液循环的研究一致。该研究发表在2009年6月的《ANTI-AGING MEDICINE》,题为《Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden》

天然虾青素是迄今为止人类在自然界发现的最强的抗氧化剂,其抗氧化能力是维生素C的6000倍维生素E的1000倍,随着相关研究的不断深入,天然虾青素强大的保健功能将进一步展现在人们面前。

 

Efficacy and safety of eight-week treatment with astaxanthin in individuals

screened forincreased oxidative stress burden

Masaaki Iwabayashi 1), Noriko Fujioka 1), Keitaro Nomoto 1), Ryo Miyazaki 1), Hozumi Takahashi 1),
Sawako Hibino 1), Yoko Takahashi 1), Koji Nishikawa 2), Mitsunori Nishida 2), Yoshikazu Yonei 1)
1) Anti-Aging Medical Research Center, Faculty of Life and Medical Sciences, Doshisha University
2) Fuji Chemical Industry Co., Ltd.

Abstract

Objective: An open-label noncontrolled study was conducted in subjects with increased oxidative stress burden to evaluate the mental and physical effects of antioxidant astaxanthin.
Methods: Of 35 healthy postmenopausal women, 21 with high oxidative stress (diacron-reactive oxygen etabolites; d-ROM) were selected, and 20 (55.7±4.8 years old, BMI 22.1±3.9) were included in the study, after excluding 1 dropout. In subjects orally treated with astaxanthin (Fuji Chemical Industry) at a daily dose of 12 mg for eight weeks, Anti-Aging QOL Common Questionnaire, somatometry, hematological examination/urinalysis, oxidative stress test, and vascular function tests (cardio ankle vascular index, CAVI; ankle brachial pressure index, ABI; fingertip acceleration pulse wave; flow-mediated dilation FMD) were performed before and four and eight weeks after the start of the study.
Results: After eight-week treatment with astaxanthin, significant improvement was observed in 5 of 34 physical symptoms listed in the common questionnaire, including “tired eyes”, “stiff shoulders”, “constipation”, “gray hair”, and “cold skin”, and in 3 of 21 mental symptoms, including “daily life is not enjoyable”, “difficulty in falling asleep”, and “a sense of tension”. In addition, systolic (118.0±16.4 mmHg at baseline, – 4.6%, p=0.021) and diastolic blood pressure (74.1±11.7 mmHg at baseline, – 6.9%, p<0.001) significantly decreased. In the vascular function test, CAVI, fingertip acceleration pulse wave, and FMD did not change, but ABI significantly increased from 1.06±0.10 at baseline to 1.10±0.06 at Week 8 (+3.7%, p=0.030). In the oxidative stress test, d-ROM did not change, but BAP significantly increased (+4.6%, p=0.030). In biochemical examination, AST (–19.2%, p=0.044), LDH (– 6.4%, p=0.006), and HbA1c (– 3.2%, p<0.001) significantly improved. Although IGF-I and insulindid not change, DHEA-s (– 15.1%, p<0.001), cortisol (– 22.8%, p=0.002), and adiponectin (– 14.1%, p=0.003) decreased. No serious adverse event occurred during or after the study. Conclusion: Results show that astaxanthin may enhance antioxidant capacity (increase BAP), reduce lower limb vascular resistance (increase ABI), decrease blood pressure, and improve physical symptoms in women with high oxidative stress.

KEY WORDS: astaxanthin, oxidative stress, vascular endothelium, pulse wave, arteriosclerosis, aging, cortisol

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