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美:国立卫生研究院:虾青素能显著减轻【脑梗塞】带来的伤害

发布日期:2016-04-18

---湖北雅仕达生物技术有限公司 研发部 李昌军 (译)
虾青素能穿透血脑屏障

     虾青素是一种有助于甲壳类动物和鱼类着色膳食类胡萝卜素,同时也是三文鱼和甲壳类动物赖以生存的重要维生素。并且已经证明虾青素能够显著减轻龋齿动物的心肌缺血性损伤。本研究的目的:检测虾青素能否有效保护哺乳动物的大脑缺血,该项目由美国国立卫生研究院的Brandon K. Harvey教授负责实施,成年大鼠注射虾青素和空白对照,然后实施人为60分钟的大脑中动脉闭塞(MCAO),结果虾青素在闭塞后的70-75分钟出现在梗塞区域,与空白对照品相比,虾青素能够显著增强中风后的大鼠活力,并且减轻大脑中动脉闭塞(MCAO)2天后梗塞的状况。为评估虾青素对中风的保护,将测试脑组织被自由基损害、凋亡和兴奋剂毒性。虾青素能拮抗缺血的顺乌头酸酶的活性丧失,降低谷氨酸的释放,脂质过氧化,细胞色素C介导转运损伤,虾青素并没有改变,如体温,脑温,脑血流量等生理参数,以及血气,血压和pH值等。总的来说,虾青素能有效地降低成年大白鼠中由缺血性脑损伤引起的伤害。虾青素能显著增强脑损伤后成年鼠的活动能力及降低脑梗死几率。研究还表明虾青素对抗缺血性脑损伤的机制为阻止脑部的氧化应激反应,减少谷氨酸盐释放,抑制细胞凋亡。最后作者还展望虾青素用于缺血性脑损伤临床上。

[阅读原文]

此研究成果发表在2009年的《The FASEB Journal》上,题为《Astaxanthin reduces ischemic brain injury in adult rats》

                                                           
 Astaxanthin reduces ischemic brain injury in adult rats

Hui Shen, Chi-Chung Kuo, Jenny Chou, Alice Delvolve, Shelley N. Jackson, Jeremy Post, Amina S. Woods, Barry J. Hoffer, Yun Wang and Brandon K. Harvey1
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
1Correspondence: National Institute on Drug Abuse, NIH, Ste. 200, Rm. 06A729, 251 Bayview Blvd., Baltimore, MD 21224, USA. E-mail:
bharvey@intra.nida.nih.gov      
Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been shown to reduce cardiac ischemic injury in rodents. The purpose of this study was to examine whether ATX can protect against ischemic injury in the mammalian brain. Adult rats were injected intracerebroventricularly with ATX or vehicle prior to a 60-min middle cerebral artery occlusion (MCAo). ATX was present in the infarction area at 70-75 min after onset of MCAo. Treatment with ATX, compared to vehicle, increased locomotor activity in stroke rats and reduced cerebral infarction at 2 d after MCAo. To evaluate the protective mechanisms of ATX against stroke, brain tissues were assayed for free radical damage, apoptosis, and excitoxicity. ATX antagonized ischemia-mediated loss of aconitase activity and reduced glutamate release, lipid peroxidation, translocation of cytochrome c, and TUNEL labeling in the ischemic cortex. ATX did not alter physiological parameters, such as body temperature, brain temperature, cerebral blood flow, blood gases, blood pressure, and pH. Collectively, our data suggest that ATX can reduce ischemia-related injury in brain tissue through the inhibition of oxidative stress, reduction of glutamate release, and antiapoptosis. ATX may be clinically useful for patients vulnerable or prone to ischemic events.—Shen, H., Kuo, C.-C., Chou, J., Delvolve, A., Jackson, S. N., Post, J., Woods, A. S., Hoffer, B. J., Wang, Y., Harvey, B. K. Astaxanthin reduces ischemic brain injury in adult rats[阅读全文]

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